So I'm trying my hand at it. Currently, I've got Derpy roaming my
tumblr for everyone to see.
I have no problem making or exporting the .gif images to use. It's just taking time. These are the two main cycles I've done of Antiquity. After I complete her, I may do Lightfoot's as well.
My OCsI used the trot cycle and standing templates that the Desktop Pony folks have for community use. I orchestrated the blink myself, as well as the mane, tail, shoes, etc.

The part I'm going to have problems with is making it into an .ini file. I have no idea how, but since it has to do with programming, I'm going to assume that any tools the Desktop Pony team have included are more suited for Windows, and I have a Mac.
If anyone has found a tutorial on how to define those interactions for your ponies (i.e., speech bubbles, making them walk around, etc.), please let me know, even if it's for Windows (I can use my desktop at home)! The only tutorials I've come across have to do with the actual gif-making.